this is so close to being a perfect wall for me that i am gonna work on it and just fiddle w it for 5 mins.. the 2d is ever so slighhty overdone in places but it would be criminal not to +fav this nonetheless
1. The 3 lines you have curving in from the left just hang there in space, no real purpose to add to the design. It's like you started em but never finished em.
2. The render is extremely compact and could be more expansive, to spead some of the detail out. There's so much at that focal point that it ends up just being a cluttered mess.
3. Your small text, microtext, and 2d work that have been sporadically placed around your piece don't seem to serve any real purpose as a design element, whether or not the text means anything doesn't matter, it's the placement of the text and its associated 2d work that matters. The 2d can be used to frame elements to a location so the eye moves with the piece and follows a path you set by using certain grid elements, thick lines and progressive text.
The one thing I am glad about (and this just may be a coincidence) is that when you used the title "Mona Lisa Overdrive" based off of the song of the same name by Juno Reactor (for the matrix movies) you kept it dark, like the song. The problem with this, however, is that the song isn't very minimal, it's exceedingly intricate and fast so I'm not so sure the title fits the piece in this situation. I suggest you pick a title first (if you hadn't already) and work your piece to convey the emotion or feeling that title portrays, or go the hard way and design first but then you really have to do some typographical research (thesaurus.com) to find a word or phrase that accurately depicts the image. In this case it seems you did the latter so give the first suggestion a try.